Cullin protein family
WebCullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination . WebCullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-∆9).
Cullin protein family
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WebUbiquitin-conjugating Enzyme E2M (UBE2M), also known as Ubiquitin-conjugating Enzyme 12 (Ubc12), is a ubiquitously expressed protein with a predicted molecular weight of 20 kDa. UBE2M/Ubc12 is highly conserved, and the human ortholog shares 100% amino acid identity with mouse and rat UBE2M. UBE2M/Ubc12 mediates conjugation of the … WebCullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals. [9] Protein function [ edit] Cullin 3 is a component of Cullin- RING E3 …
WebThis gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome … WebMay 23, 2016 · Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases.
WebEarly History of the Cullin family. This web page shows only a small excerpt of our Cullin research. Another 70 words (5 lines of text) covering the years 1659, 1300, 1534, 1517, … WebOct 15, 2015 · The cullin protein family includes scaffolding proteins that mediate substrate–receptor bindings and determine the specificity of Ub targeting for the regulation of various cellular processes [ 7 ], including proliferation, differentiation, and apoptosis. Many cullin proteins have been implicated in various cancers, including breast, skin ...
WebCullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to …
WebMar 29, 2024 · Also known as. Summary. This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and … list of hawaiian songsWebDec 12, 2002 · Cullins are a family of structurally related proteins that share a C-terminally located, evolutionarily conserved cullin domain (1, 2). It is well established that several … im an old man now songWebMicroalgae-based biodiesel production has many advantages over crude oil extraction and refinement, thus attracting more and more concern. Protein ubiquitination is a crucial mechanism in eukaryotes to regulate physiological responses and cell development, which is highly related to algal biodiesel production. Cullins as the molecular base of cullin … imanol reformas telefonoWebAbstract Cullin 4B (CUL4B), a member of the cullin protein family, is a scaffold protein of the CUL4B-RING-E3 ligase complex that ubiquitinates intracellular proteins.CUL4B's targets include cell cycle-regulated proteins and DNA replication-related molecules. list of hawaiian singersWebJan 1, 2005 · The cullin–RING ligases (CRLs) comprise a superfamily of ubiquitin ligases that are implicated in the regulation of a diverse array of eukaryotic functions. The various cullin proteins... iman on david bowieWebApr 27, 2024 · Cullin-RING ligases (CRL) are one class of E3 ubiquitin ligases that mediate polyubiquitination of specific target proteins, leading to decomposition of the substrate. Cullin 3 (CUL3) is a... list of hawaiian islands namesWebCullin 3 (Cul3) family of ubiquitin ligases comprises three components, the RING finger protein RBX1, the Cul3 scaffold, and a Bric-a-brac/Tramtrack/Broad complex (BTB) protein. The BTB protein serves as a bridge to connect Cul3 to substrate and is functionally equivalent to the combination of subst … Cullin 3 and Its Role in Tumorigenesis iman on off